Authors
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Shinji Tsukamoto
Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan.
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Kanya Honoki
Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan.
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Alberto Righi
Department of Pathology, IRCCS Rizzoli Institute, Bologna, Italy.
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Marco Gambarotti
Department of Pathology, IRCCS Rizzoli Institute, Bologna, Italy.
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Angelo Paolo Dei Tos
Department of Pathology, IRCCS Rizzoli Institute, Bologna, Italy.
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Costantino Errani
Department of Orthopaedic Oncology, IRCCS Rizzoli Institute, Bologna, Italy.
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Shingo Kishi
Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan.
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Yasuhito Tanaka
Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan.
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Hiroki Kuniyasu
Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan.
Keywords:
dedifferentiated liposarcoma; multiple lipomas; lipomatosis; 4HNE; 8-OHdG
Abstract
Lipomatosis is a diffuse overgrowth of mature adipose tissue. Point mutations in mitochondrial genes have been implicated in its pathogenesis, which increase oxidative stress. Nine cases of sarcoma associated with lipomatosis have been reported to date, of which only one was a dedifferentiated liposarcoma. We report a case of retroperitoneal primary dedifferentiated liposarcoma with pancreatic involvement and multiple metastases in soft tissue, in the context of lipomatosis. Expression of 4-hydroxy-2-nonenal and 8-hydroxy-2’-deoxyguanosine as markers of oxidative stress increased in sarcoma cells invading the pancreas. This case indicates the potential for the generation of dedifferentiated liposarcoma in lipomatosis via oxidative stress and underscores the necessity for follow-up of patients with lipomatosis.
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Author Biographies
Shinji Tsukamoto, Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan.
Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan.
Kanya Honoki, Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan.
Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan.
Alberto Righi, Department of Pathology, IRCCS Rizzoli Institute, Bologna, Italy.
Department of Pathology, IRCCS Rizzoli Institute, Bologna, Italy.
Marco Gambarotti, Department of Pathology, IRCCS Rizzoli Institute, Bologna, Italy.
Department of Pathology, IRCCS Rizzoli Institute, Bologna, Italy.
Angelo Paolo Dei Tos, Department of Pathology, IRCCS Rizzoli Institute, Bologna, Italy.
Department of Pathology, IRCCS Rizzoli Institute, Bologna, Italy.
University of Padua School of Medicine, Azienda ULSS 2 Marca Trevigiana, Treviso, Italy.
Costantino Errani, Department of Orthopaedic Oncology, IRCCS Rizzoli Institute, Bologna, Italy.
Department of Orthopaedic Oncology, IRCCS Rizzoli Institute, Bologna, Italy.
Shingo Kishi, Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan.
Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan.
Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan.
Yasuhito Tanaka, Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan.
Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan.
Hiroki Kuniyasu, Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan.
Department of Molecular Pathology, Nara Medical University, Kashihara, Nara, Japan.
