The contribution of Vitamin D on the Rehabilitation of patients with Chronic Spinal Cord Injury. Newer Data
The metabolism and actions of vitamin D in human body are nowadays under intensive investigation. Even if a lot are known about its role in the general population, a few are acquainted as for vitamin’s D effects on people who have sustained a spinal cord injury (SCI). Low mobility, poor nutritional supply and the accompanied coherences of SCI individuals makes them predominant for vitamin D deficiency in comparison to able-bodied people. The so far available studies suggest that the decreased vitamin’s D status probably have a negative action mainly on musculoskeletal system but also on cardiovascular, respiratory and endocrine system, leading to difficulties on patients attempt for rehabilitation and return to everyday activities.
Bikle DD. Vitamin D Metabolism, Mechanism of Action, and Clinical Applications. Chem Biol. 2014; 21(3): 319-29.
Lamarche J, Mailhot G. Vitamin D and spinal cord injury: should we care?. Spinal Cord 2016; 54(12): 1060–75.
McKinley WO, Gittler MS, Kirshblum SC et al. Spinal cord injury medicine. 2. Medical complications after spinal cord injury: Identification and management. Arch Phys Med Rehabil 2002; 83(3 Suppl 1): 58-64, 90-98.
Hagen EM, Rekand T, Grønning M et al. Cardiovascular complications of spinal cord injury. Tidsskr Nor Laegeforen 2012; 132(9): 1115-20.
Phillips WT, Kiratli BJ, Sarkarati M et al. Effect of spinal cord injury on the heart and cardiovascular fitness. Curr Probl Cardiol 1998; 23(11): 641-16.
Hagen EM, Faerestrand S, Hoff JM et al. Cardiovascular and urological dysfunction in spinal cord injury. Acta Neurol Scand Suppl 2011; (191): 71-8.
Jiang SD, Dai LY, Jiang LS. Osteoporosis after spinal cord injury. Osteoporos Int 2006;17(2): 180-92.
Morse LR, Batagglino RA, Stolzmann KL et al. Osteoporotic fractures and hospitalization risk in chronic spinal cord injury. Osteoporos Int 2009; 20(3): 385-92.
Duckworth WC, Jallepalli P, Solomon SS. Glucose intolerance in spinal cord injury. Arch Phys Med Rehabil 1983; 64(3): 107-10.
Vichiansiri R, Saengsuwan J, Manimmanakorn N et al. The prevalence of dyslipidemia in patients with spinal cord lesion in Thailand. Cholesterol 2012; 2012: 847462.
Norman AW, Frankel JB, Heldt AM et al. Vitamin D deﬁciency inhibits pancreatic secretion of insulin. Science 1980; 209(4458): 823-25.
Flueck JL, Perret C. Vitamin D deficiency in individuals with a spinal cord injury: a literature review. Spinal Cord 2017; 55(5): 428-34.
Nemunaitis GA, Mejia M, Nagy JA et al. A descriptive study on vitamin D levels in individuals with spinal cord injury in an acute inpatient rehabilitation setting. PM R 2010; 2(3): 202-8.
Flueck JL, Schlaepfer MW, Perret C. Effect of 12-week vitamin D supplementation on 25[OH]D status and performance in athletes with a spinal cord injury. Nutrients 2016; 8(10): 586.
Oleson CV , Patel PH, Wuermser LA. Influence of season, ethnicity, and chronicity on Vitamin D deficiency in traumatic spinal cord injury. J Spinal Cord Med 2010; 33(3): 202-13.
Robien K, Oppeneer SJ, Kelly JA et al. Drug-vitamin D interactions: a systematic review of the literature. Nutr Clin Pract 2013; 28(2): 194- 208.
Koutrakis NE, Goldstein RL, Walia P. Vitamin D, diet, and lifestyle in a chronic SCI population. Spinal Cord 2019; 57(2): 117–27.
Brown R, DiMarco AF, Hoit JD et al. Respiratory Dysfunction and Management in Spinal Cord Injury. Respir Care 2006; 51(8): 853–70.
Jaakkola MS, Jaakkola JJ, Ernst P et al. Respiratory symptoms in young adults should not be overlooked. Am Rev Respir Dis 1993; 147(2): 359–66.
Vestbo J, Rasmussen FV. Respiratory symptoms and FEV1 as predictors of hospitalization and medication in the following 12 years due to respiratory disease. Eur Respir J 1989; 2(8): 710–15.
Pfeffer PE, Hawrylowicz CM. Vitamin D and lung disease. Thorax 2012; 67(11): 1018-20.
Khoo AL, Chai L, Koenen H et al. Translating the role of vitamin D3 in infectious diseases. Crit Rev Microbiol 2012; 38(2): 122–35.
Hoyer-Hansen M, Nordbrandt SP, Jaattela M. Autophagy as a basis for the health-promoting effects of vitamin D. Trends Mol Med 2010; 16(7): 295–302.
Clark K, Goldstein RL, Hart JE, et al. Plasma vitamin D, past chest illness, and risk of future chest illness in chronic spinal cord injury (SCI): a longitudinal observational study. Spinal cord 2020; 58(4): 504-12
Garshick E, Walia P, Goldstein RL et al. Associations between vitamin D and pulmonary function in chronic spinal cord injury. J Spinal Cord Med 2019; 42(2): 171-77
Walia P, Goldstein RL, Teylan M et al. Associations between vitamin D, adiposity, and respiratory symptoms in chronic spinal cord injury. J Spinal Cord Med 2018; 41(6): 667-75.
Dauty M, Perrouin Verbe B, Maugars Y et al. Supralesional and sublesional bone mineral density in spinal cord-injured patients. Bone 2000; 27(2): 305–09.
Zehnder Y, Luthi M, Michel D et al. Long-term changes in bone metabolism, bone mineral density, quantitative ultrasound parameters, and fracture incidence after spinal cord injury:a cross-sectional observational study in 100 paraplegic men. Osteoporos Int 2004; 15(3): 180-89
Roberts D, Lee W, Cuneo RC et al. Longitudinal study of bone turnover after acute spinal cord injury. J Clin Endocrinol Metab 1998; 83(2): 415–22.
Bauman WA, Zhong Y-G, Schwartz E. Vitamin D deﬁciency in veterans with chronic spinal cord injury. Metabolism 1995; 44(12): 1612–16.
Karapolat I, Karapolat HU, KIrazlI Y et al. Longitudinal study of bone loss in chronic spinal cord injury patients. J Phys Ther Sci 2015; 27(5): 1429-33.
Vaziri ND, Pandiun MR, Segal JL et al. Vitamin D, Parathormone, and Calcitonin Profiles in Persons With Long-Standing Spinal Cord Injury. Arch Phys Med Rehabil 1994; 75(7): 766-69.
Morse LR , Nguyen N , Battaglino RA et al. Wheelchair use and Lipophilic Statin Medications May Influence Bone Loss in Chronic Spinal Cord Injury: Findings from the FRASCI-bone loss Study. Osteoporos Int 2016; 27(12): 3503-11.
Jørgensen V, Slettahjell HB, Roaldse KS et al. Carboxy terminal collagen crosslinks as a prognostic risk factor for fall-related fractures in individuals with established spinal cord injury. Spinal Cord 2019; 57(11): 985-91.
Bauman WA, Spungen AM, Morisson N et al. Effect of a vitamin D analog on leg bone mineral density in patients with chronic spinal cord injury. J Rehabil Res Rev 2005; 42(5): 625-34.
Girgis CM, Clifton-Bligh RJ, Turner N et al. Effects of vitamin D in skeletal muscle: falls, strength, athletic performance and insulin sensitivity. Clin Endocrinol (Oxf) 2014; 80(2): 169-81
Girgis CM, Clifton-Bligh RJ, Mokbel N et al. Vitamin D signaling regulates proliferation, differentiation, and myotube size in C2C12 skeletal muscle cells. Endocrinology 2014; 155(2): 347–57
Ceglia L, da Silva Morais M, Park LK et al. Multi-step immunoﬂuorescent analysis of vitamin D receptor loci and myosin heavy chain isoforms in human skeletal muscle. J Mol Histol 2010; 41(2-3): 137-42
Wagatsuma A, Sakuma K. Vitamin D signaling in myogenesis: potential for treatment of sarcopenia. Biomed Res Int 2014; 2014: 121254.
Girgis CM, Clifton-Bligh RJ, Mokbel N et al. Vitamin D signaling regulates proliferation, differentiation, and myotube size in C2C12 skeletal muscle cells. Endocrinology 2014; 155(2): 347-57.
Girgis CM, Clifton-Bligh RJ, Hamrick MW et al. The roles of vitamin D in skeletal muscle: form, function, and metabolism. Endocr Rev 2013; 34(1): 33–83.
Barbonetti A, D’Andrea S, Martorella A et al. Low vitamin D levels are independent predictors of 1-year worsening in physical function in people with chronic spinal cord injury: a longitudinal study. Spinal Cord 2018; 56(5): 494-01.
Barbonetti A, Sperandio A, Micillo A et al. Independent Association of Vitamin D with Physical Function in People with Chronic Spinal Cord Injury. Arch Phys Med Rehabil 2016; 97(5): 726-32.
Wong KE, Szeto FL, Zhang W et al. Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins. Am J Physiol 2009; 296(4): 820-28.
Reid IR. Effects of calcium supplementation on circulating lipids: potential pharmacoeconomic implications. Drugs Aging 2004; 21(1): 7 –17
McCarty DE, Chesson AL Jr, Jain SK et al. The link between vitamin D metabolism and sleep medicine. Sleep Med Rev 2014; 18(4): 311-19
Taniguchi A, Kataoka K, Kono T et al. Parathyroid hormone-induced lipolysis in human adipose tissue. J Lipid Res 1987; 28(5): 490 –94.
Beal C, Gorgey A, Moore P. Higher dietary intake of vitamin D may influence total cholesterol and carbohydrate profile independent of body composition in men with Chronic Spinal Cord Injury. J Spinal Cord Med 2018; 41(4): 459-70.
C, Béraud-Dufour S, Devader C et al. Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin. J Diabetes Res 2016; 2016: 3142175.
Bland R, Markovic D, Hills CE et al. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol 2004;89-90(1-5):121-25.
Lee S, Clark SA, Gill RK et al. 1,25-Dihydroxyvitamin D3 and pancreatic beta-cell function: vitamin D receptors, gene expression, and insulin secretion. Endocrinology 1994; 134(4): 1602-10
Maestro B, Campion J, Davila N et al. Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J 2000 ;47(4): 383-91
Weaver FM, Collins EG, Kurichi J et al. Prevalence of obesity and high blood pressure in veterans with spinal cord injuries and disorders: a retrospective review. Am J Phys Med Rehabil 2007; 86(1): 22-29.
Jones LM, Legge M, Goulding A. Healthy body mass index values often underestimate body fat in men with spinal cord injury. Arch Phys Med Rehabil 2003; 84(7): 1068–71.
Gorgey AS, Dolbow DR, Dolbow JD et al. Effects of spinal cord injury on body composition and metabolic profile – Part I. J Spinal Cord Med 2014; 37(4): 693–02.
Wortsman J, Matsuoka LY, Chen TC et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72(3): 690-93.
Ajabshir S, Asif A, Nayer A. The effects of vitamin D on the rennin-angiotensin system. J Nephropathol 2014; 3(2): 41-43.
Pilz S, Tomaschitz A, Ritz E et al. Vitamin D status and arterial hypertension: a systematic review. Nat Rev Cardiol 2009; 6(10): 621-30.
Dong J, Wong SL, Lau CW et al. Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. Eur Heart J 2012; 33(23): 2980–90.
Sakellariou VI, Grigoriou E, Mavrogenis AF et al. Heterotopic ossiﬁcation following traumatic brain injury and spinal cord injury: An insight into the etiology and pathophysiology. J Musculoskelet Neuronal Interact 2012; 12(4): 230 –40
van Kuijk AA, Geurts AC, van Kuppevelt HJ. Neurogenic heterotopic ossiﬁcation in spinal cord injury. Spinal Cord 2002; 40(7): 313-26.
Ish-Shalom S, Segal E, Salganik T et al. Comparison of daily, weekly, and monthly vitamin D3 in ethanol dosing protocols for two months in elderly hip fracture patients. J Clin Endocrinol Metab 2008; 93(9): 3430-35.
Heaney RP, Recker RR, Grote J et al. Vitamin D(3) is more potent than vitamin D(2) in humans. J Clin Endocrinol Metab 2011; 96(3): E447–52.
Holick MF, Biancuzzo RM, Chen TC et al. Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab 2008; 93(3): 677-81.
Bauman WA, Emmons RR, Cirnigliaro CM et al. An effective oral vitamin D replacement therapy in persons with spinal cord injury. J Spinal Cord Med 2011; 34( 5): 455-60.
Bauman WA, Morrison NG, Spungen AM. Vitamin D Replacement Therapy In Persons With Spinal Cord Injury. J Spinal Cord Med 2005; 28(3): 203-07.
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