Botox applications in patients with neurological symptoms following Spinal Cord Injury

  • A. Paila
  • M.E. Evangelopoulos
Keywords: Spinal Cord Injury, Botox, Spasticity, Urinary system, Pain


Spinal cord injury (SCI) is defined as damage to the spinal cord causing temporary or permanent changes in patient’s major functions. The main type of SCI occurs from direct trauma, as in accidents, and is called traumatic. Despite scientific and therapeutic progress, traumatic SCI remains a major cause of morbidity and mortality. Its long-term medical complications have serious consequences for patients and their families; therefore, finding effective therapeutic interventions is very important. This study is a review of the existing literature on the therapeutic effects of botulinum toxin (Botox) as an intervention for the treatment of neurological complications occurring in patients after SCI, with emphasis on chronic complications. Botox is produced by the bacterium Clostridium botulinum, which causes botulism in humans. There are seven immunogenic toxins, however, the most used formula is BoNT-A. Botox treatment in patients with SCI is effective against spasticity, bladder dysfunction and chronic pain.


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Author Biographies

A. Paila

Postgraduate training program: “Rehabilitation following Spinal Cord lesions. Spinal Pain Management”, National and Kapodistrian University of Athens, KAT Hospital, Athens, Greece

M.E. Evangelopoulos

Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Greece


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