Biological therapies for the treatment of early stage pre-collapse osteonecrosis of the femoral head

  • Ioannis K. Triantafyllopoulos
  • Athanasios Papavasiliou
Keywords: osteonecrosis, femoral head, core decompression, cell therapy, stem cells

Abstract

The pathogenetic mechanism for non-traumatic osteonecrosis of the femoral head (ONFH) remains elusive.  It is known, that an important part of the underlying pathology in ON is cell deficiency, hence, it is rational to consider the use of cell-based treatments to supplement more established surgical interventions. This chapter will focus surgically on Core Decompression (CD) and discuss a number of its technical advancements and variations.  It will also focus on cell-based therapies that attempt to improve simple CD outcomes and argue their variability and safety. 

Author Biographies

Ioannis K. Triantafyllopoulos

Assistant Professor of Orthopaedics, MD, MSci, PhD, FEBOT, Head of the 5th Orthopaedic Department

Athanasios Papavasiliou

BSc, MD, PhD, Orthopaedic Surgeon, Interbalkan European Medical Centre Thessaloniki, Greece

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Published
2020-03-24