Vitamin D and musculoskeletal health
Keywords:
Vitamin D ; Metabolic bone disorders ; Musculoskeletal health
Abstract
Vitamin D is a steroid pro-hormone, with effects that are not limited to the metabolism of calcium and phosphorus, but are pleiotropic and involve cellular differentiation, the immune response, intermediate metabolism and the cardiovascular system. This fat-soluble vitamin plays a significant role in musculoskeletal homeostasis and its deficiency or mal-regulatory function leads to several bone metabolic disorders.
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References
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2. Holick MF. Vitamin D Deficiency N Engl J Med 2007; 357:266-81.
3. Rosen CJ. Vitamin D Insufficiency N Engl J Med 2011; 364:248-54
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8. Pettifor JM, Prentice A. The role of vitamin D in paediatric bone health. Best Practice and Research Clin Endocrinol & Metabol 2011; 25:573-584.
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15. Heaney RP, Dowell MS, Hale CA, Bendich A. Calcium Absorption Varies within the Reference Range for Serum 25-Hydroxyvitamin D. Journal of the American College of Nutrition, 2003; 22: 142–146.
16. Gallagher JC, Yalamanchili V, Smith LM. The effect of vitamin D on calcium absorption in older women. J Clin Endocrinol Metab. 2012; 97:3550-6.
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18. Bischoff-Ferrari HA. Vitamin D and Fracture Prevention. Endocrinol Metab Clin N Am 2010; 39: 347-353.
19. Cauley JA, Danielson ME, Boudreau R, Barbour KE, Horwitz MJ, Bauer DC, Ensrud KE, Manson JE, Wactawski‐Wende J, Shikany JM, Jackson RD. Serum 25‐hydroxyvitamin D and clinical fracture risk in a multiethnic cohort of women: The women’s health initiative (WHI). J Bone Mineral Research 2011; 26:2378–2388.
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21. Murad MH, Elamin KB, Abu Elnour NO, Elamin MB, Alkatib AA, Fatourechi MM, Almandoz JP, Mullan RJ, Lane MA, Liu H, Erwin PJ, Hensrud DD, Montori VM. The Effect of Vitamin D on Falls: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metabol 2011; 96: 2997–3006.
22. Thandrayen Κ, Pettifor JM. Maternal Vitamin D Status: Implications for the Development of Infantile Nutritional Rickets. Endocrinol Metab Clin N Am 2010; 39: 303-320.
23. Chawes BL, Bønnelykke K, Stokholm J, et al. Effect of Vitamin D3 Supplementation During Pregnancy on Risk of Persistent Wheeze in the Offspring: A Randomized Clinical Trial. JAMA. 2016 ;315:353-61.
24. Litonjua AA, Carey VJ, Laranjo N, et al. Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial.JAMA. 2016 ;315:362-70.
25. von Mutius E, Martinez FD. Inconclusive Results of Randomized Trials of Prenatal Vitamin D for Asthma Prevention in Offspring: Curbing the Enthusiasm. JAMA. 2016 ;315:347-8.
26. Cooper C, Harvey NC, Bishop NJ, et al; MAVIDOS Study Group. Maternal gestational vitamin D supplementation and offspring bone health (MAVIDOS): a multicentre, double-blind, randomised placebo-controlled trial. Lancet Diabetes Endocrinol. 2016;4:393-402.
27. Dusso A, Gonzalez EA, Martin KJ. Vitamin D in chronic kidney disease. Best Practice and Research Clin Endocrinol & Metabol 2011; 25: 647-655.
28. Holic MF. Vitamin D: Extraskeletal Health. Endocrinol Metab Clin N Am 2010; 39: 381-400.
29. Cianferotti L, Bertoldo F, Bischoff-Ferrari HA, et al. Vitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults: research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO). Endocrine 2017 in press.
30. Heaney RP, Armas LAG, Shary JR, Bell NH, Binkley N, Hollis BW. 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. Am J Clin Nutr 2008; 87:1738–42.
31. Armas LAG, Hollis BW, Heaney RP. Vitamin D2 Is Much Less Effective than Vitamin D3 in Humans. J Clin Endocrinol Metab 2004; 89: 5387–5391.
32. Romagnoli E, Mascia ML, Cipriani C, Fassino V, Mazzei F, D’Erasmo Ε, Carnevale V, Scillitani A, Minisola S. Short and Long-Term Variations in Serum Calciotropic Hormones after a Single Very Large Dose of Ergocalciferol (Vitamin D2) or Cholecalciferol (Vitamin D3) in the Elderly. J Clin Endocrinol Metab 2008; 93: 3015–3020.
33. Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, Nicholson GC. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA. 2010 303:1815-22.
34. Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, Staehelin HB, Meyer OW, Theiler R, Dick W, Willett WC, Egli A. Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern Med. 2016; 176:175-83.
35. Smith LM, Gallagher JC, Suiter C. Medium doses of daily vitamin D decrease falls and higher doses of daily vitamin D3 increase falls: A randomized clinical trial.J Steroid Biochem Mol Biol. 2017; in press doi: 10.1016/j.jsbmb.2017.03.015
36. Tebben PJ, Singh RJ, Kumar R. Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment. Endocr Rev. 2016;37:521-547.
2. Holick MF. Vitamin D Deficiency N Engl J Med 2007; 357:266-81.
3. Rosen CJ. Vitamin D Insufficiency N Engl J Med 2011; 364:248-54
4. Boillon R. comparative analysis of nutritional guidelines for vitamin D. Nature Rev Endo 2017; in press, doi: 10.1038/nrendo.2017.31
5. Lieben L, Carmeliet G, Masuyama R. Calcemic actions of vitamin D: Effects on the intestine, kidney and bone. Best Practice and Research Clin Endocrinol & Metabol 2011; 25:561-572
6. Cashman KD, Dowling KG, Skrabáková Zet al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr. 2016; 103:1033-44.
7. Cloutier M, Gascon‐Barré M, D’Amour P. Chronic adaptation of dog parathyroid function to a low‐calcium‐high‐Sodium‐Vitamin D‐deficient diet. J Bone Miner Research 1992; 7:1021-1028.
8. Pettifor JM, Prentice A. The role of vitamin D in paediatric bone health. Best Practice and Research Clin Endocrinol & Metabol 2011; 25:573-584.
9. Munns CF, Shaw N, Kiely M, et al Global Consensus Recommendations on prevention and Management of Nutritional Rickets. Horm Res Paediatr 2016; 85:83–106.
10. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA. The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know. J Clin Endocrinol Metabol 2011; 96:53-58.
11. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metabol 2011; 96: 1911-1930.
12. Bhan A, Rao AD, Rao SD. Osteomalacia as a Result of Vitamin D Deficiency Endocrinol Metab Clin N Am 2010; 39: 321–331.
13. Dawson-Hughes B, Mithal A, Bonjour JP, Boonen S, Burckhardt P, Fuleihan GEH, Josse RG, Lips P, Morales-Torres J, Yoshimura N. IOF position statement: vitamin D recommendations for older adults. Osteoporos Int 2010; 21:1151–1154.
14. Rizzoli R, Boonen S, Brandi ML, et al. Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Curr Med Res Opin. 2013; 29:305-13.
15. Heaney RP, Dowell MS, Hale CA, Bendich A. Calcium Absorption Varies within the Reference Range for Serum 25-Hydroxyvitamin D. Journal of the American College of Nutrition, 2003; 22: 142–146.
16. Gallagher JC, Yalamanchili V, Smith LM. The effect of vitamin D on calcium absorption in older women. J Clin Endocrinol Metab. 2012; 97:3550-6.
17. Fuleihan Gel-H, Bouillon R, Clarke B, Chakhtoura M, Cooper C, McClung M, Singh RJ . Serum 25-Hydroxyvitamin D Levels: Variability, Knowledge Gaps, and the Concept of a Desirable Range. J Bone Miner Res. 2015; 30:1119-33.
18. Bischoff-Ferrari HA. Vitamin D and Fracture Prevention. Endocrinol Metab Clin N Am 2010; 39: 347-353.
19. Cauley JA, Danielson ME, Boudreau R, Barbour KE, Horwitz MJ, Bauer DC, Ensrud KE, Manson JE, Wactawski‐Wende J, Shikany JM, Jackson RD. Serum 25‐hydroxyvitamin D and clinical fracture risk in a multiethnic cohort of women: The women’s health initiative (WHI). J Bone Mineral Research 2011; 26:2378–2388.
20. Weaver CM, Alexander DD, Boushey CJ, et al. Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int. 2016; 27:367-76.
21. Murad MH, Elamin KB, Abu Elnour NO, Elamin MB, Alkatib AA, Fatourechi MM, Almandoz JP, Mullan RJ, Lane MA, Liu H, Erwin PJ, Hensrud DD, Montori VM. The Effect of Vitamin D on Falls: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metabol 2011; 96: 2997–3006.
22. Thandrayen Κ, Pettifor JM. Maternal Vitamin D Status: Implications for the Development of Infantile Nutritional Rickets. Endocrinol Metab Clin N Am 2010; 39: 303-320.
23. Chawes BL, Bønnelykke K, Stokholm J, et al. Effect of Vitamin D3 Supplementation During Pregnancy on Risk of Persistent Wheeze in the Offspring: A Randomized Clinical Trial. JAMA. 2016 ;315:353-61.
24. Litonjua AA, Carey VJ, Laranjo N, et al. Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial.JAMA. 2016 ;315:362-70.
25. von Mutius E, Martinez FD. Inconclusive Results of Randomized Trials of Prenatal Vitamin D for Asthma Prevention in Offspring: Curbing the Enthusiasm. JAMA. 2016 ;315:347-8.
26. Cooper C, Harvey NC, Bishop NJ, et al; MAVIDOS Study Group. Maternal gestational vitamin D supplementation and offspring bone health (MAVIDOS): a multicentre, double-blind, randomised placebo-controlled trial. Lancet Diabetes Endocrinol. 2016;4:393-402.
27. Dusso A, Gonzalez EA, Martin KJ. Vitamin D in chronic kidney disease. Best Practice and Research Clin Endocrinol & Metabol 2011; 25: 647-655.
28. Holic MF. Vitamin D: Extraskeletal Health. Endocrinol Metab Clin N Am 2010; 39: 381-400.
29. Cianferotti L, Bertoldo F, Bischoff-Ferrari HA, et al. Vitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults: research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO). Endocrine 2017 in press.
30. Heaney RP, Armas LAG, Shary JR, Bell NH, Binkley N, Hollis BW. 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. Am J Clin Nutr 2008; 87:1738–42.
31. Armas LAG, Hollis BW, Heaney RP. Vitamin D2 Is Much Less Effective than Vitamin D3 in Humans. J Clin Endocrinol Metab 2004; 89: 5387–5391.
32. Romagnoli E, Mascia ML, Cipriani C, Fassino V, Mazzei F, D’Erasmo Ε, Carnevale V, Scillitani A, Minisola S. Short and Long-Term Variations in Serum Calciotropic Hormones after a Single Very Large Dose of Ergocalciferol (Vitamin D2) or Cholecalciferol (Vitamin D3) in the Elderly. J Clin Endocrinol Metab 2008; 93: 3015–3020.
33. Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, Nicholson GC. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA. 2010 303:1815-22.
34. Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, Staehelin HB, Meyer OW, Theiler R, Dick W, Willett WC, Egli A. Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern Med. 2016; 176:175-83.
35. Smith LM, Gallagher JC, Suiter C. Medium doses of daily vitamin D decrease falls and higher doses of daily vitamin D3 increase falls: A randomized clinical trial.J Steroid Biochem Mol Biol. 2017; in press doi: 10.1016/j.jsbmb.2017.03.015
36. Tebben PJ, Singh RJ, Kumar R. Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment. Endocr Rev. 2016;37:521-547.
Published
2023-06-26
Section
Review
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